ISSN 2146-8133
 

Original Research (Original Article) Open Access


Tumor expression of Nectin-4 as a prognostic marker in breast cancer

Hisham Al-Torky, Galal Aboul-Nagah, Tarek El-Fayomi, Hytham Fayed, Hanan Tayel, Mahmoud Sakr.

Abstract
Background: Identification of new molecular tumor associated biomarkers is the most important current challenge in cancer research. Nectin-4 is one of the Nectin glycoproteins, which are cell adhesion molecules have been involved in tumor biology.
Objectives: The objective was to evaluate Nectin-4 expression by immunohistochemistry (IHC) as a prognostic tumor marker in breast cancer (BC).
Patients and Methods: This study was carried out on 100 female patients with BC. Their ages ranged between 29 and 67 years, with a mean of 41.3 years. Fifty other age-matched patients, subjected to reduction mammoplasty, served as controls. Data collected prospectively included patient demographics and tumor characteristics, including histopathological type and grade, IHC for Nectin-4 expression, estrogen receptors (ER), progesterone receptors (PR), and human epidermal growth factor receptor 2 (HER2-Neu). Patients were regularly followed-up for 2 years, recording loco-regional recurrence, distant metastasis, and mortality.
Results: Nectin-4 expression by IHC was detected in 62% of BC patients, but in none of the tumor-free controls (P = 0.0001). Nectin-4 expression showed a statistically significant positive correlation with higher tumor grade (P = 0.003) and axillary lymph node involvement (P = 0.0001), but not with increasing tumor size (P = 0.273). It had a significant inverse correlation with ER and PR, and a significant positive correlation with HER2-Neu (P = 0.0001). Furthermore, there was a significant correlation between Nectin-4 expression and the development of distant metastases (P = 0.014), local recurrence (P = 0.046), and mortality (P = 0.049).
Conclusions: Nectin-4 is a highly recommended biomarker for predicting progression and prognosis of BC.

Key words: Breast cancer, prognosis, tumor markers, Nectin-4, immunohistochemistry


 
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How to Cite this Article
Pubmed Style

Al-Torky H, Aboul-Nagah G, El-Fayomi T, Fayed H, Tayel H, Sakr M. Tumor expression of Nectin-4 as a prognostic marker in breast cancer. Arch Clin Exp Surg. 2015; 4(4): 178-184. doi:10.5455/aces.20140404063752


Web Style

Al-Torky H, Aboul-Nagah G, El-Fayomi T, Fayed H, Tayel H, Sakr M. Tumor expression of Nectin-4 as a prognostic marker in breast cancer. http://www.ejmaces.com/?mno=152711 [Access: February 25, 2018]. doi:10.5455/aces.20140404063752


AMA (American Medical Association) Style

Al-Torky H, Aboul-Nagah G, El-Fayomi T, Fayed H, Tayel H, Sakr M. Tumor expression of Nectin-4 as a prognostic marker in breast cancer. Arch Clin Exp Surg. 2015; 4(4): 178-184. doi:10.5455/aces.20140404063752



Vancouver/ICMJE Style

Al-Torky H, Aboul-Nagah G, El-Fayomi T, Fayed H, Tayel H, Sakr M. Tumor expression of Nectin-4 as a prognostic marker in breast cancer. Arch Clin Exp Surg. (2015), [cited February 25, 2018]; 4(4): 178-184. doi:10.5455/aces.20140404063752



Harvard Style

Al-Torky, H., Aboul-Nagah, G., El-Fayomi, T., Fayed, H., Tayel, H. & Sakr, M. (2015) Tumor expression of Nectin-4 as a prognostic marker in breast cancer. Arch Clin Exp Surg, 4 (4), 178-184. doi:10.5455/aces.20140404063752



Turabian Style

Al-Torky, Hisham, Galal Aboul-Nagah, Tarek El-Fayomi, Hytham Fayed, Hanan Tayel, and Mahmoud Sakr. 2015. Tumor expression of Nectin-4 as a prognostic marker in breast cancer. Archives of Clinical and Experimental Surgery (ACES), 4 (4), 178-184. doi:10.5455/aces.20140404063752



Chicago Style

Al-Torky, Hisham, Galal Aboul-Nagah, Tarek El-Fayomi, Hytham Fayed, Hanan Tayel, and Mahmoud Sakr. "Tumor expression of Nectin-4 as a prognostic marker in breast cancer." Archives of Clinical and Experimental Surgery (ACES) 4 (2015), 178-184. doi:10.5455/aces.20140404063752



MLA (The Modern Language Association) Style

Al-Torky, Hisham, Galal Aboul-Nagah, Tarek El-Fayomi, Hytham Fayed, Hanan Tayel, and Mahmoud Sakr. "Tumor expression of Nectin-4 as a prognostic marker in breast cancer." Archives of Clinical and Experimental Surgery (ACES) 4.4 (2015), 178-184. Print. doi:10.5455/aces.20140404063752



APA (American Psychological Association) Style

Al-Torky, H., Aboul-Nagah, G., El-Fayomi, T., Fayed, H., Tayel, H. & Sakr, M. (2015) Tumor expression of Nectin-4 as a prognostic marker in breast cancer. Archives of Clinical and Experimental Surgery (ACES), 4 (4), 178-184. doi:10.5455/aces.20140404063752





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