E-ISSN 2146-8133
 

Review Article 


A Review of the Prevention and Treatment of Hypertrophic Scars: Part I Clinical Aspects

Huseyin Karagoz, Celalettin Sever, Yalcin Bayram, Cihan Sahin, Yalcin Kulahci, Ersin Ulkur.

Cited by (2)

Abstract
The therapeutic management of hypertrophic scars remains challenging. Numerous methods have been described for the treatment of hypertrophic scars but, to date, the optimal treatment method has not been established. The aim of this review is to discuss the therapeutic modalities in the light of current literature, and to guide regarding the choice of treatment methods for physicians. The surgical and non-surgical treatment and prevention methods of the hypertrophic scars were reviewed and some recommendations for physicians who try to treat or prevent the hypertrophic scar were developed under cover of current literature and our personal experiences. A lot of therapeutic modalities have been described for the hypertrophic scars so far, but there is no absolute curative method alone. The most appropriate method or methods should be selected according to the patient’s needs and properties of the scar. The therapists can benefit from our review when they select the most appropriate method or methods for treatment of hypertrophic scars.

Key words: Hypertrophic scar, prevention, treatment


 
ARTICLE TOOLS
Abstract
PDF Fulltext
Print this article Print this Article
How to cite this articleHow to cite this article
Export to
Export to
Related Records
 Articles by Huseyin Karagoz
Articles by Celalettin Sever
Articles by Yalcin Bayram
Articles by Cihan Sahin
Articles by Yalcin Kulahci
Articles by Ersin Ulkur
on Google
on Google Scholar
Article Statistics
 Viewed: 4829
Downloaded: 808
Cited: 2

REFERENCES
1. Wang XQ, Liu YK, Qing C, Lu SL. A review of the effectiveness of antimitotic drug injections for hypertrophic scars and keloids. Ann Plast Surg 2009;63:688-692.

http://dx.doi.org/10.1097/SAP.0b013e3181978753

[Pubmed]   

2. de Oliveira GV, Nunes TA, Magna LA, Cintra ML, Kitten GT, Zarpellon S, et al. Silicone versus nonsilicone gel dressings: a controlled trial. Dermatol Surg 2001;27:721-726.

http://dx.doi.org/10.1046/j.1524-4725.2001.00345.x

[
Pubmed]   

3. Baisch A, Riedel F. [Hyperplastic scars and keloids. Part I: basics and prevention].[Article in German]. HNO 2006;54:893-904.

http://dx.doi.org/10.1007/s00106-006-1462-z

[
Pubmed]   

4. Mustoe TA, Cooter RD, Gold MH, Hobbs FD, Ramelet AA, Shakespeare PG, et al. Internationalclinicalrecommendations on scarmanagement.International Advisory Panel on ScarManagement. Plast Reconstr Surg 2002;110:560-571.

http://dx.doi.org/10.1097/00006534-200208000-00031

[
Pubmed]   

5. Mutalik S.Treatment of keloids and hypertrophic scars. Indian J Dermatol Venereol Leprol2005;71:3-8.

http://dx.doi.org/10.4103/0378-6323.13777

[
Pubmed]   

6. Ogawa R.The most currentalgorithms for the treatment and prevention of hypertrophic scars and keloids.PlastReconstr Surg 2010;125:557-568.

http://dx.doi.org/10.1097/PRS.0b013e3181c82dd5

[
Pubmed]   

7. Broughton G 2nd, Rohrich RJ. Wounds and Scars. Selected Readings in Plastic Surgery, Volume 10, number 7, part I, 2005;5-7.


8. Hyakusoku H, Ogawa R. The small-wave incision for long keloids. Plast Reconstr Surg 2003;111:964-965.

http://dx.doi.org/10.1097/00006534-200302000-00101

[
Pubmed]   

9. Huang C, Ono S, Hyakusoku H, Ogawa R. Small-wave incision method for linear hypertrophic scar reconstruction: a parallel-group randomized controlled study. Aesthetic Plast Surg 2012;36:387-395.

http://dx.doi.org/10.1007/s00266-011-9821-x

[
Pubmed]   

10. Atiyeh BS. Nonsurgical management of hypertrophic scars: evidence-based therapies, standard practices, and emerging methods. Aesthetic Plast Surg 2007;31:468-492.

http://dx.doi.org/10.1007/s00266-006-0253-y

[
Pubmed]   

11. Larson DL, Abston S, Evans EB, Dobrkovsky M, Linares HA. Techniques for decreasing scar formation and contractures in the burned patient. J Trauma 1971;11:807-823.

http://dx.doi.org/10.1097/00005373-197110000-00001

[
Pubmed]   

12. Larson DL, Abston S, Willis B, Linares H, Dobrkovsky M, Evans EB, et al. Contracture and scarformation in the burnpatient.Clin Plast Surg 1974;1:653-656.

[
Pubmed]   

13. Renò F, Sabbatini M, Lombardi F, Stella M, Pezzuto C, Magliacani G, et al. In vitro mechanical compression induces apoptosis and regulates cytokines release in hypertrophic scars. Wound Repair Regen 2003;11:331-336.

http://dx.doi.org/10.1046/j.1524-475X.2003.11504.x

[
Pubmed]   

14. Macintyre L, Baird M. Pressuregarments for use in the treatment of hypertrophic scars--a review of the problemsassociated with their use.Burns 2006;32:10-15.

http://dx.doi.org/10.1016/j.burns.2004.06.018

[
Pubmed]   

15. Reid WH, Evans JH, Naismith RS, Tully AE, Sherwin S. Hypertrophic scarring and pressuretherapy.Burns Incl Therm Inj 1987;13 Suppl:S29-32.

http://dx.doi.org/10.1016/0305-4179(87)90090-8


16. Ward RS. Pressuretherapy for the control of hypertrophic scar formation after burn injury. A history and review. J Burn Care Rehabil. 1991;12:257-262.

http://dx.doi.org/10.1097/00004630-199105000-00011

[
Pubmed]   

17. Puzey G. The use of pressure garments on hypertrophic scars.J Tissue Viability 2002;12:11-15.

[
Pubmed]   

18. Steinstraesser L, Flak E, Witte B, Ring A, Tilkorn D, Hauser J, et al. Pressure garment therapy alone and in combination with silicone for the prevention of hypertrophic scarring: randomized controlled trial with intraindividual comparison. Plast Reconstr Surg 2011;128:306e-313e.

http://dx.doi.org/10.1097/PRS.0b013e3182268c69

[
Pubmed]   

19. Anzarut A, Olson J, Singh P, Rowe BH, Tredget EE. The effectiveness of pressuregarmenttherapy for the prevention of abnormalscarringafterburninjury: a meta-analysis. J Plast Reconstr Aesthet Surg 2009;62:77-84.

http://dx.doi.org/10.1016/j.bjps.2007.10.052

[
Pubmed]   

20. Cheng JC, Evans JH, Leung KS, Clark JA, Choy TT, Leung PC. Pressuretherapy in the treatment of post-burnhypertrophicscar--a criticallook into its usefulness and fallacies by pressuremonitoring. Burns Incl Therm Inj 1984;10:154-163.

http://dx.doi.org/10.1016/0305-4179(84)90020-2


21. Rose MP, Deitch EA. The clinical use of a tubular compression bandage, Tubigrip, for burn-scar therapy: a critical analysis. Burns Incl Therm Inj 1985;12:58-64.

http://dx.doi.org/10.1016/0305-4179(85)90184-6


22. Chang P, Laubenthal KN, Lewis RW 2nd, Rosenquist MD, Lindley-Smith P, Kealey GP. Prospective, randomized study of the efficacy of pressuregarment therapy in patients with burns. J Burn Care Rehabil 1995;16:473-475.

http://dx.doi.org/10.1097/00004630-199509000-00002

[
Pubmed]   

23. Brown CA. A comparison of the outcomes of twoclinicalaudits of burnpressuregarmentsatisfaction and compliance in SaudiArabia.Burns 2001;27:342-348.

http://dx.doi.org/10.1016/S0305-4179(00)00139-X


24. LeVier RR, Harrison MC, Cook RR, Lane TH. What is silicone? Plast Reconstr Surg 1993;92:163-167.

http://dx.doi.org/10.1097/00006534-199307000-00028

[
Pubmed]   

25. Kuhn MA, Moffit MR, Smith PD, Lyle WG, Ko F, Meltzer DD, et al. Siliconesheetingdecreasesfibroblastactivity and downregulatesTGFbeta2 in hypertrophicscarmodel. Int J Surg Investig 2001;2:467-474.

[
Pubmed]   

26. Shih R, Waltzman J, Evans GR. Review of over-the-countertopicalscartreatmentproducts.Plastic Surgery Educational Foundation Technology Assessment Committee. Plast Reconstr Surg 2007;119:1091-1095.

http://dx.doi.org/10.1097/01.prs.0000255814.75012.35

[
Pubmed]   

27. Hanasono MM, Lum J, Carroll LA, Mikulec AA, Koch RJ. The effect of siliconegel on basicfibroblastgrowthfactorlevels in fibroblastcellculture. Arch Facial Plast Surg 2004;6:88-93.

http://dx.doi.org/10.1001/archfaci.6.2.88

[
Pubmed]   

28. Berman B, Perez OA, Konda S, Kohut BE, Viera MH, Delgado S, et al. A review of the biologic effects, clinical efficacy, and safety of silicone elastomer sheeting for hypertrophic and keloid scartreatment and management. Dermatol Surg 2007;33:1291-1302.

http://dx.doi.org/10.1111/j.1524-4725.2007.33280.x

[
Pubmed]   

29. Eishi K, Bae SJ, Ogawa F, Hamasaki Y, Shimizu K, Katayama I. Siliconegelsheetsrelievepain and pruritus with clinicalimprovement of keloid: possibletarget of mastcells. J Dermatolog Treat 2003;14:248-252.

http://dx.doi.org/10.1080/09546630310016808

[
Pubmed]   

30. Santucci M, Borgognoni L, Reali UM, Gabbiani G. Keloids and hypertrophicscars of Caucasians show distinctivemorphologic and immunophenotypicprofiles. Virchows Arch 2001;438:457-463.

http://dx.doi.org/10.1007/s004280000335

[
Pubmed]   

31. Ricketts CH, Martin L, Faria DT, Saed GM, Fivenson DP. CytokinemRNAchanges during the treatment of hypertrophicscars with silicone and nonsiliconegeldressings. Dermatol Surg 1996;22:955-959.

http://dx.doi.org/10.1016/S1076-0512(96)00429-3


32. Lindberg M, Forslind B. The effects of occlusion of the skin on the Langerhans' cell and the epidermal mononuclear cells. Acta Derm Venereol 1981;61:201-205.

[
Pubmed]   

33. Mikulowska A. Reactivechanges in the Langerhans' cells of humanskincaused by occlusion with water and sodiumlaurylsulphate. Acta Derm Venereol 1990;70:468-473.

[
Pubmed]   

34. Chan KY, Lau CL, Adeeb SM, Somasundaram S, Nasir-Zahari M. A randomized, placebo-controlled, double-blind, prospectiveclinicaltrial of siliconegel in prevention of hypertrophicscardevelopment in mediansternotomywound. Plast Reconstr Surg 2005;116:1013-1020.

http://dx.doi.org/10.1097/01.prs.0000178397.05852.ce

[
Pubmed]   

35. Karagoz H, Yuksel F, Ulkur E, Evinc R. Comparison of efficacy of silicone gel, silicone gelsheeting, and topical onion extract including heparin and allantoin for the treatment of postburn hypertrophic scars. Burns 2009;35:1097-1103.

http://dx.doi.org/10.1016/j.burns.2009.06.206

[
Pubmed]   

36. Signorini M, Clementoni MT. Clinical evaluation of a new self-drying siliconegel in the treatment of scars: a preliminary report. Aesthetic Plast Surg 2007;31:183-187.

http://dx.doi.org/10.1007/s00266-005-0122-0

[
Pubmed]   

37. Carney SA, Cason CG, Gowar JP, Stevenson JH, McNee J, Groves AR, et al. Cica-Care gel sheeting in the management of hypertrophic scarring. Burns 1994;20:163-167.

http://dx.doi.org/10.1016/S0305-4179(06)80016-1


38. Berman B, Flores F. Comparison of a siliconegel-filled cushion and silicon gel sheeting for the treatment of hypertrophic or keloid scars. Dermatol Surg 1999;25:484-486.

http://dx.doi.org/10.1046/j.1524-4725.1999.08292.x

[
Pubmed]   

39. Poston J. The use of siliconegel sheeting in the management of hypertrophic and keloid scars. J Wound Care 2000;9:10-16.

[
Pubmed]   

40. Ahn ST, Monafo WW, Mustoe TA. Topical siliconegel: a new treatment for hypertrophic scars.Surgery 1989;106:781-786.

[
Pubmed]   

41. Gold MH. A controlled clinicaltrial of topical siliconegel sheeting in the treatment of hypertrophic scars and keloids. J Am Acad Dermatol 1994;30:506-507.

http://dx.doi.org/10.1016/S0190-9622(08)81956-1


42. Katz BE. Silicone gel sheeting in scar therapy. Cutis 1995;56:65-67.

[
Pubmed]   

43. Li-Tsang CW, Lau JC, Choi J, Chan CC, Jianan L. A prospective randomized clinical trial to investigate the effect of silicone gel sheeting (Cica-Care) on post-traumatic hypertrophic scar among the Chinese population. Burns 2006;32:678-683.

http://dx.doi.org/10.1016/j.burns.2006.01.016

[
Pubmed]   

44. Gold MH, Foster TD, Adair MA, Burlison K, Lewis T. Prevention of hypertrophic scars and keloids by the prophylactic use of topical silicone gel sheets following a surgical procedure in an office setting. Dermatol Surg 2001;27:641-644.

http://dx.doi.org/10.1046/j.1524-4725.2001.00356.x

[
Pubmed]   

45. Maján JI. Evaluation of a self-adherentsoftsiliconedressing for the treatment of hypertrophicpostoperativescars. J Wound Care 2006;15:193-196.

[
Pubmed]   

46. Manuskiatti W, Fitzpatrick RE. Treatment response of keloidal and hypertrophic sternotomy scars: comparison among intralesional corticosteroid, 5-fluorouracil, and 585-nm flashlamp-pumped pulsed-dye laser treatments. Arch Dermatol 2002;138:1149-1155.

http://dx.doi.org/10.1001/archderm.138.9.1149

[
Pubmed]   

47. Roques C, Téot L. The use of corticosteroids to treat keloids: a review.Int J Low Extrem Wounds 2008;7:137-145.

http://dx.doi.org/10.1177/1534734608320786

[
Pubmed]   

48. Niessen FB, Spauwen PH, Schalkwijk J, Kon M. On the nature of hypertrophicscars and keloids: a review. Plast Reconstr Surg 1999;104:1435-1458.

http://dx.doi.org/10.1097/00006534-199910000-00031

[
Pubmed]   

49. Tang YW. Intra- and postoperative steroid injections for keloids and hypertrophicscars. Br J Plast Surg 1992;45:371-373.

http://dx.doi.org/10.1016/0007-1226(92)90007-K


50. Urioste SS, Arndt KA, Dover JS. Keloids and hypertrophic scars: review and treatment strategies. Semin Cutan Med Surg 1999;18:159-171.

http://dx.doi.org/10.1016/S1085-5629(99)80040-6


51. Fitzpatrick RE. Treatment of inflamed hypertrophic scars using intralesional 5-FU. Dermatol Surg 1999;25:224-232.

http://dx.doi.org/10.1046/j.1524-4725.1999.08165.x

[
Pubmed]   

52. de Waard JW, de Man BM, Wobbes T, van der Linden CJ, Hendriks T. Inhibition of fibroblast collagen synthesis and proliferation by levamisole and 5-fluorouracil. Eur J Cancer 1998;34:162-167.

http://dx.doi.org/10.1016/S0959-8049(97)00352-3


53. Liu W, Wu X, Gao Z. Newpotentialantiscarringapproaches.Wound Repair Regen 2011;19 Suppl 1:s22-31.

http://dx.doi.org/10.1111/j.1524-475X.2011.00710.x

[
Pubmed]   

54. Liu W, Wu X, Gao Z, Song N. Remodelling of keloidtissue into normal-lookingskin. J Plast Reconstr Aesthet Surg 2008;61:1553-1554.

http://dx.doi.org/10.1016/j.bjps.2008.08.003

[
Pubmed]   

55. España A, Solano T, Quintanilla E. Bleomycin in the treatment of keloids and hypertrophic scars by multiple needle punctures. Dermatol Surg 2001;27:23-27.

http://dx.doi.org/10.1111/j.1524-4725.2001.99315.x

[
Pubmed]   

56. Naeini FF, Najafian J, Ahmadpour K. Bleomycintattooing as a promisingtherapeuticmodality in largekeloids and hypertrophicscars. Dermatol Surg 2006;32:1023-1029.

http://dx.doi.org/10.1111/j.1524-4725.2006.32225.x

[
Pubmed]   

57. Saray Y, Güleç AT. Treatment of keloids and hypertrophicscars with dermojet injections of bleomycin: a preliminary study. Int J Dermatol 2005;44:777-784.

http://dx.doi.org/10.1111/j.1365-4632.2005.02633.x

[
Pubmed]   

58. Aggarwal H, Saxena A, Lubana PS, Mathur RK, Jain DK. Treatment of keloids and hypertrophicscars using bleom. J Cosmet Dermatol 2008;7:43-49.

http://dx.doi.org/10.1111/j.1473-2165.2008.00360.x

[
Pubmed]   

59. Berman B, Duncan MR. Short-term keloid treatment in vivo with human interferon alfa-2b results in a selective and persistent normalization of keloidal fibroblast collagen, glycosaminoglycan, and collagenase production in vitro.J Am Acad Dermatol 1989;21(4 Pt 1):694-702.

http://dx.doi.org/10.1016/S0190-9622(89)70239-5


60. Berman B, Flores F. Recurrence rates of excised keloids treated with postoperative triamcinolone acetonide injections or interferon alfa-2b injections. J Am Acad Dermatol 1997;37(5 Pt 1):755-757.

http://dx.doi.org/10.1016/S0190-9622(97)70113-0


61. Tredget EE, Shankowsky HA, Pannu R, Nedelec B, Iwashina T, Ghahary A, et al. Transforminggrowthfactor-beta in thermallyinjuredpatients with hypertrophicscars: effects of interferonalpha-2b. Plast Reconstr Surg 1998;102:1317-1328.

http://dx.doi.org/10.1097/00006534-199810000-00001

[
Pubmed]   

62. Alster TS, West TB. Treatment of scars: a review. Ann Plast Surg 1997;39:418-432.

http://dx.doi.org/10.1097/00000637-199710000-00014

[
Pubmed]   

63. Nouri K, Vidulich K, Rivas MP. Lasers for scars: a review. J Cosmet Dermatol 2006;5:14-22.

http://dx.doi.org/10.1111/j.1473-2165.2006.00217.x

[
Pubmed]   

64. Acikel C, Ergun O, Ulkur E, Servet E, Celikoz B. Camouflage of self-inflicted razor blade incision scars with carbon dioxide laser resurfacing and thin skin grafting. Plast Reconstr Surg 2005;116:798-804.

http://dx.doi.org/10.1097/01.prs.0000176256.87404.dd

[
Pubmed]   

65. Alster TS. Improvement of erythematous and hypertrophic scars by the 585-nm flashlamp-pumped pulsed dye laser. Ann Plast Surg 1994;32:186-190.

http://dx.doi.org/10.1097/00000637-199402000-00015

[
Pubmed]   

66. Goldman MP, Fitzpatrick RE. Laser treatment of scars. Dermatol Surg 1995;21:685-687.

[
Pubmed]   

67. Wittenberg GP, Fabian BG, Bogomilsky JL, Schultz LR, Rudner EJ, Chaffins ML, et al. Prospective, single-blind, randomized, controlledstudy to assess the efficacy of the 585-nmflashlamp-pumpedpulsed-dyelaser and siliconegelsheeting in hypertrophicscartreatment. Arch Dermatol1999;135:1049-1055.

http://dx.doi.org/10.1001/archderm.135.9.1049

[
Pubmed]   

68. Har-Shai Y, Amar M, Sabo E. Intralesionalcryotherapy for enhancing the involution of hypertrophicscars and keloids. Plast Reconstr Surg 2003;111:1841-1852.

http://dx.doi.org/10.1097/01.PRS.0000056868.42679.05

[
Pubmed]   

69. Davey RB, Wallis KA, Bowering K. Adhesive contact media--an update on graft fixation and burn scar management. Burns 1991;17:313-319.

http://dx.doi.org/10.1016/0305-4179(91)90047-K


70. Reiffel RS. Prevention of hypertrophic scars by long-termpapertapeapplication.Plast Reconstr Surg 1995;96:1715-1718.

http://dx.doi.org/10.1097/00006534-199512000-00031

[
Pubmed]   

71. Khoo TL, Halim AS, Zakaria Z, Mat Saad AZ, Wu LY, Lau HY. A prospective, randomised, double-blindedtrial to study the efficacy of topicaltocotrienol in the prevention of hypertrophicscars. J Plast Reconstr Aesthet Surg 2011;64:e137-145.

http://dx.doi.org/10.1016/j.bjps.2010.08.029

[
Pubmed]   

72. Satterfield D, Taube D, Kenney MC. Effect of vitaminE on the production of collagen, DNA and fibronectin in keratocytes in vitro. Ophthalmic Res 1988;20:227-231.

http://dx.doi.org/10.1159/000266648

[
Pubmed]   

73. Haas AL, Boscoboinik D, Mojon DS, Böhnke M, Azzi A. Vitamin Einhibitsproliferation of humanTenon's capsulefibroblastsin vitro. Ophthalmic Res 1996;28:171-175.

http://dx.doi.org/10.1159/000267899

[
Pubmed]   

74. Jenkins M, Alexander JW, MacMillan BG, Waymack JP, Kopcha R. Failure of topical steroids and vitamin E to reduce postoperative scar formation following reconstructive surgery. J Burn Care Rehabil 1986;7:309-312.

http://dx.doi.org/10.1097/00004630-198607000-00002

[
Pubmed]   

75. Baumann LS, Spencer J. The effects of topical vitaminE on the cosmetic appearance of scars. Dermatol Surg 1999;25:311-315.

http://dx.doi.org/10.1046/j.1524-4725.1999.08223.x

[
Pubmed]   

76. Zampieri N, Zuin V, Burro R, Ottolenghi A, Camoglio FS. A prospectivestudy in children: Pre- and post-surgery use of vitaminE in surgicalincisions. J Plast Reconstr Aesthet Surg 2010;63:1474-1478.

http://dx.doi.org/10.1016/j.bjps.2009.08.018

[
Pubmed]   

77. Perez OA, Viera MH, Patel JK, Konda S, Amini S, Huo R, et al. A comparativestudyevaluating the tolerability and efficacy of twotopicaltherapies for the treatment of keloids and hypertrophicscars. J Drugs Dermatol 2010;9:514-518.

[
Pubmed]   

78. Fan SQ, Cai JL, Qin LY, Wang ZH, Liu ZZ, Sun ML. Effect of heparin on production of transforming growth factor (TGF)-beta1 and TGF-beta1 mRNA expression by human normal skin and hyperplastic scar fibroblasts. Ann Plast Surg 2008;60:299-305.

http://dx.doi.org/10.1097/SAP.0b013e318061d310

[
Pubmed]   

79. Beuth J, Hunzelmann N, Van Leendert R, Basten R, Noehle M, Schneider B. Safety and efficacy of localadministration of contractubex to hypertrophicscars in comparison to corticosteroidtreatment. Results of a multicenter, comparativeepidemiologicalcohortstudy in Germany. In Vivo 2006;20:277-283.

[
Pubmed]   

80. Ho WS, Ying SY, Chan PC, Chan HH. Use of onion extract, heparin, allantoin gel in prevention of scarring in chinese patients having laser removal of tattoos: a prospective randomized controlled trial. Dermatol Surg 2006;32:891-896.

http://dx.doi.org/10.1111/j.1524-4725.2006.32192.x

[
Pubmed]   

81. Chen MA, Davidson TM. Scar management: prevention and treatment strategies. Curr Opin Otolaryngol Head Neck Surg 2005;13:242-247.

http://dx.doi.org/10.1097/01.moo.0000170525.74264.f8

[
Pubmed]   

82. Phan TT, Lim IJ, Chan SY, Tan EK, Lee ST, Longaker MT. Suppression of transforming growth factor beta/smadsignaling in keloid-derivedfibroblasts by quercetin: implications for the treatment of excessivescars. J Trauma 2004;57:1032-1037.

http://dx.doi.org/10.1097/01.TA.0000114087.46566.EB

[
Pubmed]   

83. Roques C. Massage applied to scars. Wound Repair Regen 2002;10:126-128.

http://dx.doi.org/10.1046/j.1524-475X.2002.02107.x

[
Pubmed]   

84. Patiño O, Novick C, Merlo A, Benaim F. Massage in hypertrophic scars. J Burn Care Rehabil 1999;20:268-271.

[
Pubmed]   

85. Ogawa R, Mitsuhashi K, Hyakusoku H, Miyashita T. Postoperativeelectron-beamirradiationtherapy for keloids and hypertrophicscars: retrospectivestudy of 147casesfollowed for more than 18months. Plast Reconstr Surg 2003;111:547-553.

http://dx.doi.org/10.1097/01.PRS.0000040466.55214.35

[
Pubmed]   

86. Ogawa R, Miyashita T, Hyakusoku H, Akaishi S, Kuribayashi S, Tateno A. Postoperativeradiationprotocol for keloids and hypertrophicscars: statisticalanalysis of 370sitesfollowed for over18months. Ann Plast Surg 2007;59:688-691.

http://dx.doi.org/10.1097/SAP.0b013e3180423b32

PMid:18046154

This Article Cited By the following articles

Unusual ignition of a bullet causing hand injury: Case report
Injury Extra 2014; 45(1): 9-11.

1
 
A REVIEW OF THE PREVENTION AND TREATMENT OF HYPERTROPHIC SCARS: PART II EXPERIMENTAL STUDIES
Archives of Clinical and Experimental Surgery (ACES) 2012; (): 1.

2
 

How to Cite this Article
Pubmed Style

Karagoz H, Sever C, Bayram Y, Sahin C, Kulahci Y, Ulkur E. A Review of the Prevention and Treatment of Hypertrophic Scars: Part I Clinical Aspects. Arch Clin Exp Surg. 2012; 1(4): 237-248. doi:10.5455/aces.20120218124923


Web Style

Karagoz H, Sever C, Bayram Y, Sahin C, Kulahci Y, Ulkur E. A Review of the Prevention and Treatment of Hypertrophic Scars: Part I Clinical Aspects. http://www.ejmaces.com/?mno=15345 [Access: May 27, 2018]. doi:10.5455/aces.20120218124923


AMA (American Medical Association) Style

Karagoz H, Sever C, Bayram Y, Sahin C, Kulahci Y, Ulkur E. A Review of the Prevention and Treatment of Hypertrophic Scars: Part I Clinical Aspects. Arch Clin Exp Surg. 2012; 1(4): 237-248. doi:10.5455/aces.20120218124923



Vancouver/ICMJE Style

Karagoz H, Sever C, Bayram Y, Sahin C, Kulahci Y, Ulkur E. A Review of the Prevention and Treatment of Hypertrophic Scars: Part I Clinical Aspects. Arch Clin Exp Surg. (2012), [cited May 27, 2018]; 1(4): 237-248. doi:10.5455/aces.20120218124923



Harvard Style

Karagoz, H., Sever, C., Bayram, Y., Sahin, C., Kulahci, Y. & Ulkur, E. (2012) A Review of the Prevention and Treatment of Hypertrophic Scars: Part I Clinical Aspects. Arch Clin Exp Surg, 1 (4), 237-248. doi:10.5455/aces.20120218124923



Turabian Style

Karagoz, Huseyin, Celalettin Sever, Yalcin Bayram, Cihan Sahin, Yalcin Kulahci, and Ersin Ulkur. 2012. A Review of the Prevention and Treatment of Hypertrophic Scars: Part I Clinical Aspects. Archives of Clinical and Experimental Surgery (ACES), 1 (4), 237-248. doi:10.5455/aces.20120218124923



Chicago Style

Karagoz, Huseyin, Celalettin Sever, Yalcin Bayram, Cihan Sahin, Yalcin Kulahci, and Ersin Ulkur. "A Review of the Prevention and Treatment of Hypertrophic Scars: Part I Clinical Aspects." Archives of Clinical and Experimental Surgery (ACES) 1 (2012), 237-248. doi:10.5455/aces.20120218124923



MLA (The Modern Language Association) Style

Karagoz, Huseyin, Celalettin Sever, Yalcin Bayram, Cihan Sahin, Yalcin Kulahci, and Ersin Ulkur. "A Review of the Prevention and Treatment of Hypertrophic Scars: Part I Clinical Aspects." Archives of Clinical and Experimental Surgery (ACES) 1.4 (2012), 237-248. Print. doi:10.5455/aces.20120218124923



APA (American Psychological Association) Style

Karagoz, H., Sever, C., Bayram, Y., Sahin, C., Kulahci, Y. & Ulkur, E. (2012) A Review of the Prevention and Treatment of Hypertrophic Scars: Part I Clinical Aspects. Archives of Clinical and Experimental Surgery (ACES), 1 (4), 237-248. doi:10.5455/aces.20120218124923





Most Viewed Articles
  • Hirudotherapy /Leech therapy: Applications and Indications in Surgery
    Swaid Abdullah, Latief M. Dar, Adil Rashid, Anita Tewari
    Arch Clin Exp Surg. 2012; 1(3): 172-180
    » Abstract & References » doi: 10.5455/aces.20120402072447

  • Role of Probiotics in Dental Caries and Periodontal Disease
    Amit Bhardwaj, Shalu V Bhardwaj
    Arch Clin Exp Surg. 2012; 1(1): 45-49
    » Abstract & References » doi: 10.5455/aces.20120212100645

  • Attenuated familial adenomatous polyposis presenting as an abdominal wall mass
    Marc Paul Jose Lopez, John Paul Senon Gonzalez, Manuel Francisco Tanada Roxas
    Arch Clin Exp Surg. 2017; 6(1): 53-55
    » Abstract » doi: 10.5455/aces.20150809085449

  • Use of Polyethylene Fiber (Ribbond) in Pediatric Dentistry
    Eda Arat Maden, Ceyhan Altun
    Arch Clin Exp Surg. 2012; 1(2): 110-115
    » Abstract & References » doi: 10.5455/aces.20120416115640

  • Role of Ultrasonography (“Honeycomb Sign”) in Early Detection of Dengue Hemorrhagic Fever
    Sudhir Sachar, Sunder Goyal, Saurabh Sachar
    Arch Clin Exp Surg. 2013; 2(1): 38-42
    » Abstract & References » doi: 10.5455/aces.20120828025157

  • Barium Enema in the Diagnosis of Hirschsprung’s Disease: A Comparison with Rectal Biopsy
    Mohammad Abbas, Arshad Rashid, Asim Rafiq Laharwal, Ajaz Ahmad Wani, Shabir Ahmad Dar, Manzoor Ahamad Chalkoo, Showkat Majeed Kakroo
    Arch Clin Exp Surg. 2013; 2(4): 224-228
    » Abstract & References » doi: 10.5455/aces.20120703031135

  • Long-Term Productive Cough Caused by Tracheal Bronchus
    Chih-Hao Chen, Shih-Yi Lee, Ho Chang, Tzu-Ti Hung
    Arch Clin Exp Surg. 2012; 1(2): 120-121
    » Abstract & References » doi: 10.5455/aces.20120311102403

  • A Review of the Prevention and Treatment of Hypertrophic Scars: Part I Clinical Aspects
    Huseyin Karagoz, Celalettin Sever, Yalcin Bayram, Cihan Sahin, Yalcin Kulahci, Ersin Ulkur
    Arch Clin Exp Surg. 2012; 1(4): 237-248
    » Abstract & References » doi: 10.5455/aces.20120218124923

  • Day–Care Surgery for Pilonidal Sinus Using Sinotomy Technique and Fibrin Glue Injection
    Selim Sozen, Vedat Ozturk, Koray Das, Hasan Erdem, Suleyman Cetinkunar, Ilhan Bali
    Arch Clin Exp Surg. 2012; 1(3): 138-141
    » Abstract & References » doi: 10.5455/aces.20120625121721

  • Scorpion sting in a pregnant woman: A case report
    Selim Bozkurt, Mehmet Okumus, Besime Utku, Deniz Cemgil Arikan, Ugur Lok, Fatma Betul Duygu
    Arch Clin Exp Surg. 2015; 4(2): 118-120
    » Abstract & References » doi: 10.5455/aces.20121229025033

  • Most Downloaded
  • Attenuated familial adenomatous polyposis presenting as an abdominal wall mass
    Marc Paul Jose Lopez, John Paul Senon Gonzalez, Manuel Francisco Tanada Roxas
    Arch Clin Exp Surg. 2017; 6(1): 53-55
    » Abstract » doi: 10.5455/aces.20150809085449

  • Role of Probiotics in Dental Caries and Periodontal Disease
    Amit Bhardwaj, Shalu V Bhardwaj
    Arch Clin Exp Surg. 2012; 1(1): 45-49
    » Abstract & References » doi: 10.5455/aces.20120212100645

  • Patient Selection in Plastic Surgery: Recognizing Body Dysmorphic Disorder
    Cihan Sahin, Onat Yilmaz, Yalcin Bayram, Huseyin Karagoz, Celalettin Sever, Yalcin Kulahci, Alpay Ates
    Arch Clin Exp Surg. 2013; 2(2): 109-115
    » Abstract & References » doi: 10.5455/aces.20120722123102

  • Hirudotherapy /Leech therapy: Applications and Indications in Surgery
    Swaid Abdullah, Latief M. Dar, Adil Rashid, Anita Tewari
    Arch Clin Exp Surg. 2012; 1(3): 172-180
    » Abstract & References » doi: 10.5455/aces.20120402072447

  • Use of Polyethylene Fiber (Ribbond) in Pediatric Dentistry
    Eda Arat Maden, Ceyhan Altun
    Arch Clin Exp Surg. 2012; 1(2): 110-115
    » Abstract & References » doi: 10.5455/aces.20120416115640

  • A Study of Methods Used to Reduce Surgical Site Infections
    Stuart R. Walker, Tara Anderson
    Arch Clin Exp Surg. 2012; 1(1): 27-33
    » Abstract & References » doi: 10.5455/aces.20120213053645

  • Slow-Release Drug Deliver System with Polylactic Acid Hydrogels in Prevention of Tracheal Wall Fibroplasia
    Jinrang Li, Lili Peng, Jianjun Sun, Hongguang Guo, Kun Guo, Zuogang Li, Yao Tang, Xu Sun, Shuangqing Zhang
    Arch Clin Exp Surg. 2012; 1(1): 1-7
    » Abstract & References » doi: 10.5455/aces.20120220105531

  • Principles of risk management in surgery departments
    Fatemeh Rezaei, Mohammad H Yarmohammadian, Masoud Ferdosi, Abbas Haghshenas
    Arch Clin Exp Surg. 2015; 4(3): 126-134
    » Abstract & References » doi: 10.5455/aces.20140925015830

  • Post-Traumatic Pancreatic Pseudocyst: Report of Two Cases with Review of Literature
    Sunder Goyal, Sudhir Sachar, Ram Kumar Verma, Snigdha Goyal
    Arch Clin Exp Surg. 2013; 2(4): 251-258
    » Abstract & References » doi: 10.5455/aces.20120524103614

  • A Review of the Prevention and Treatment of Hypertrophic Scars: Part I Clinical Aspects
    Huseyin Karagoz, Celalettin Sever, Yalcin Bayram, Cihan Sahin, Yalcin Kulahci, Ersin Ulkur
    Arch Clin Exp Surg. 2012; 1(4): 237-248
    » Abstract & References » doi: 10.5455/aces.20120218124923

  • Most Cited Articles
  • Hirudotherapy /Leech therapy: Applications and Indications in Surgery
    Swaid Abdullah, Latief M. Dar, Adil Rashid, Anita Tewari
    Arch Clin Exp Surg. 2012; 1(3): 172-180
    » Abstract & References » doi: 10.5455/aces.20120402072447
    Cited : 8 times [Click to see citing articles]

  • Experimental Craniofacial Composite Tissue Allotransplantation (CCTA) Models in Rats
    Yalcin Kulahci, Yalcin Bayram, Huseyin Karagoz, Celalettin Sever, Cihan Sahin
    Arch Clin Exp Surg. 2012; 1(3): 181-187
    » Abstract & References » doi: 10.5455/aces.20120514010906
    Cited : 7 times [Click to see citing articles]

  • Thoracodorsal Artery Perforator Flap: Basic Surgical Determinants
    Celalettin Sever, Yalcin Bayram, Cihan Sahin
    Arch Clin Exp Surg. 2012; 1(4): 270-271
    » Abstract & References » doi: 10.5455/aces.20120506072849
    Cited : 6 times [Click to see citing articles]

  • Pre-expanded Supraclavicular Flap for Post-burn Neck Contractures
    Celalettin Sever, Cihan Sahin
    Arch Clin Exp Surg. 2012; 1(1): 61-62
    » Abstract & References » doi: 10.5455/aces.20120205090034
    Cited : 4 times [Click to see citing articles]

  • Day–Care Surgery for Pilonidal Sinus Using Sinotomy Technique and Fibrin Glue Injection
    Selim Sozen, Vedat Ozturk, Koray Das, Hasan Erdem, Suleyman Cetinkunar, Ilhan Bali
    Arch Clin Exp Surg. 2012; 1(3): 138-141
    » Abstract & References » doi: 10.5455/aces.20120625121721
    Cited : 4 times [Click to see citing articles]

  • The effect of Kristeller maneuver on maternal and neonatal outcome
    Gokhan Acmaz, Evrim Albayrak, Gokalp Oner, Murvet Baser, Gulsum Aykut, Gulender Tas Tekin, Gokmen Zararsiz, Iptisam Ipek Muderris
    Arch Clin Exp Surg. 2015; 4(1): 29-35
    » Abstract & References » doi: 10.5455/aces.20140328024258
    Cited : 4 times [Click to see citing articles]

  • What is the Most Appropriate Animal Model for Experimental Diabetic Neuropathy Studies ?
    Huseyin Karagoz, Mustafa Tansel Kendirli
    Arch Clin Exp Surg. 2012; 1(3): 199-200
    » Abstract & References » doi: 10.5455/aces.20120514012617
    Cited : 3 times [Click to see citing articles]

  • Anesthetic Burns – A Burn Injury Due to A Combination of Local Anaesthetic and Heat Pack
    Stuart Robert Walker
    Arch Clin Exp Surg. 2012; 1(2): 127-128
    » Abstract & References » doi: 10.5455/aces.20120206110836
    Cited : 3 times [Click to see citing articles]

  • A Review of the Prevention and Treatment of Hypertrophic Scars: Part II. Experimental Studies
    Huseyin Karagoz, Yalcin Bayram, Celalettin Sever, Cihan Sahin, Yalcin Kulahci, Ersin Ulkur
    Arch Clin Exp Surg. 2013; 2(1): 49-58
    » Abstract & References » doi: 10.5455/aces.20120218125115
    Cited : 3 times [Click to see citing articles]

  • Students’ View of Evidence-Based Medicine: A Survey in Switzerland
    Reto Kaderli, Larissa Burghardt, Carina Hansali, Adrian Businger
    Arch Clin Exp Surg. 2012; 1(1): 34-40
    » Abstract & References » doi: 10.5455/aces.20120217124737
    Cited : 3 times [Click to see citing articles]