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Original Research (Original Article) 


The effects of locally applied procaine on wound healing

Arzu Akcal, Semra Karsidag, Kemalettin Yildiz, Nebil Yesiloglu, Mehmet Akif Akcal, Fevziye Kabukcuoglu.

Abstract
Objective: The goals of this study were: (1) To determine the efficacy of 2% procaine (the most commonly used concentra- tion) in wound healing; and (2) To determine the proper open wound injection site.
Materials and Methods: Thirty adult male Sprague-Dawley rats weighing between 250 and 350 g were used. Two full thickness defects were made on two sides of the midline 1 cm away from midline. The skin wound areas were approxi- mately 1.5 cm × 1.5 cm. The animals were randomly divided into three groups: Group 1 (control group, n = 8), Group 2 (injection directly into the base of wound, n = 8), and Group 3 (injection into healthy skin around the peripheral margins of the wound, n = 8). Mechanical analyses of wound tensile strength of were evaluated in all groups.
Results: Wound closure was first seen in Group 3 on day 14. Mean wound healing times were 18.25 days, 16.25 days, and 15.62 days, and mean tensile strength was 777.13 cN, 988.25 cN, and 1068.25 cN in the Groups 1, 2, and 3 respectively.
Conclusions: Procaine did not cause any necrosis around the wound, did not retard wound healing, did not cause circu- lation deficiency, and did not reduce the breaking strength of the wound. Therefore, it can be safely used to reduce pain around the wound and to accelerate the healing process of slow-to-heal wounds.

Key words: Procaine, slow-to-heal wounds, tensile strength


 
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How to Cite this Article
Pubmed Style

Akcal A, Karsidag S, Yildiz K, Yesiloglu N, Akcal MA, Kabukcuoglu F. The effects of locally applied procaine on wound healing. Arch Clin Exp Surg. 2015; 4(1): 41-45. doi:10.5455/aces.20140606054447


Web Style

Akcal A, Karsidag S, Yildiz K, Yesiloglu N, Akcal MA, Kabukcuoglu F. The effects of locally applied procaine on wound healing. http://www.ejmaces.com/?mno=153763 [Access: May 26, 2018]. doi:10.5455/aces.20140606054447


AMA (American Medical Association) Style

Akcal A, Karsidag S, Yildiz K, Yesiloglu N, Akcal MA, Kabukcuoglu F. The effects of locally applied procaine on wound healing. Arch Clin Exp Surg. 2015; 4(1): 41-45. doi:10.5455/aces.20140606054447



Vancouver/ICMJE Style

Akcal A, Karsidag S, Yildiz K, Yesiloglu N, Akcal MA, Kabukcuoglu F. The effects of locally applied procaine on wound healing. Arch Clin Exp Surg. (2015), [cited May 26, 2018]; 4(1): 41-45. doi:10.5455/aces.20140606054447



Harvard Style

Akcal, A., Karsidag, S., Yildiz, K., Yesiloglu, N., Akcal, M. A. & Kabukcuoglu, F. (2015) The effects of locally applied procaine on wound healing. Arch Clin Exp Surg, 4 (1), 41-45. doi:10.5455/aces.20140606054447



Turabian Style

Akcal, Arzu, Semra Karsidag, Kemalettin Yildiz, Nebil Yesiloglu, Mehmet Akif Akcal, and Fevziye Kabukcuoglu. 2015. The effects of locally applied procaine on wound healing. Archives of Clinical and Experimental Surgery (ACES), 4 (1), 41-45. doi:10.5455/aces.20140606054447



Chicago Style

Akcal, Arzu, Semra Karsidag, Kemalettin Yildiz, Nebil Yesiloglu, Mehmet Akif Akcal, and Fevziye Kabukcuoglu. "The effects of locally applied procaine on wound healing." Archives of Clinical and Experimental Surgery (ACES) 4 (2015), 41-45. doi:10.5455/aces.20140606054447



MLA (The Modern Language Association) Style

Akcal, Arzu, Semra Karsidag, Kemalettin Yildiz, Nebil Yesiloglu, Mehmet Akif Akcal, and Fevziye Kabukcuoglu. "The effects of locally applied procaine on wound healing." Archives of Clinical and Experimental Surgery (ACES) 4.1 (2015), 41-45. Print. doi:10.5455/aces.20140606054447



APA (American Psychological Association) Style

Akcal, A., Karsidag, S., Yildiz, K., Yesiloglu, N., Akcal, M. A. & Kabukcuoglu, F. (2015) The effects of locally applied procaine on wound healing. Archives of Clinical and Experimental Surgery (ACES), 4 (1), 41-45. doi:10.5455/aces.20140606054447





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