E-ISSN 2146-8133
 

Original Research (Original Article) 


Acceleration of Medpor implant fibrovascularization with local vascular endothelial growth-factor injections: An experimental study

Mert Demirel, Burak Kaya, Aylin Okcu Heper, Murat Emiroglu.

Abstract
Objective: Medpor is a biocompatible, high-density porous polyethylene implant that is used for multiple indications in plastic surgery. The most frequent complications associated with the Medpor implant are infection and implant exposure. The primary cause of these complications is poor fibrovascularization of the Medpor implant and poor nourishment of the overlying skin. The present experimental study aimed to determine whether vascular endothelial growth factor (VEGF) could accelerate and increase Medpor implant fibrovascularization in vivo, and thereby improve local nourishment and prevent complications.
Materials and Methods: The Medpor implant was inserted under the dorsal skin area in 40 Sprague-Dawley rats. 20 rats receiving local VEGF injections comprised the study group. The control group received saline injections. Fibrovascularization of the Medpor implants was compared.
Results: In the rats injected with VEGF, the Medpor implant fibrovascularized faster, and there were more newly formed blood vessels, as compared with those in the control group.
Conclusion: These findings have led to our use of VEGF-like agents that the accelerate angiogenesis in the Medpor implant as a means to reduce the incidence of such complications as infection and implant exposure.

Key words: Angiogenesis, fibrovascularization, Medpor, vascular endothelial growth factor


 
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How to Cite this Article
Pubmed Style

Demirel M, Kaya B, Heper AO, Emiroglu M. Acceleration of Medpor implant fibrovascularization with local vascular endothelial growth-factor injections: An experimental study. Arch Clin Exp Surg. 2015; 4(4): 196-201. doi:10.5455/aces.20150107042453


Web Style

Demirel M, Kaya B, Heper AO, Emiroglu M. Acceleration of Medpor implant fibrovascularization with local vascular endothelial growth-factor injections: An experimental study. http://www.ejmaces.com/?mno=172506 [Access: August 17, 2018]. doi:10.5455/aces.20150107042453


AMA (American Medical Association) Style

Demirel M, Kaya B, Heper AO, Emiroglu M. Acceleration of Medpor implant fibrovascularization with local vascular endothelial growth-factor injections: An experimental study. Arch Clin Exp Surg. 2015; 4(4): 196-201. doi:10.5455/aces.20150107042453



Vancouver/ICMJE Style

Demirel M, Kaya B, Heper AO, Emiroglu M. Acceleration of Medpor implant fibrovascularization with local vascular endothelial growth-factor injections: An experimental study. Arch Clin Exp Surg. (2015), [cited August 17, 2018]; 4(4): 196-201. doi:10.5455/aces.20150107042453



Harvard Style

Demirel, M., Kaya, B., Heper, A. O. & Emiroglu, M. (2015) Acceleration of Medpor implant fibrovascularization with local vascular endothelial growth-factor injections: An experimental study. Arch Clin Exp Surg, 4 (4), 196-201. doi:10.5455/aces.20150107042453



Turabian Style

Demirel, Mert, Burak Kaya, Aylin Okcu Heper, and Murat Emiroglu. 2015. Acceleration of Medpor implant fibrovascularization with local vascular endothelial growth-factor injections: An experimental study. Archives of Clinical and Experimental Surgery (ACES), 4 (4), 196-201. doi:10.5455/aces.20150107042453



Chicago Style

Demirel, Mert, Burak Kaya, Aylin Okcu Heper, and Murat Emiroglu. "Acceleration of Medpor implant fibrovascularization with local vascular endothelial growth-factor injections: An experimental study." Archives of Clinical and Experimental Surgery (ACES) 4 (2015), 196-201. doi:10.5455/aces.20150107042453



MLA (The Modern Language Association) Style

Demirel, Mert, Burak Kaya, Aylin Okcu Heper, and Murat Emiroglu. "Acceleration of Medpor implant fibrovascularization with local vascular endothelial growth-factor injections: An experimental study." Archives of Clinical and Experimental Surgery (ACES) 4.4 (2015), 196-201. Print. doi:10.5455/aces.20150107042453



APA (American Psychological Association) Style

Demirel, M., Kaya, B., Heper, A. O. & Emiroglu, M. (2015) Acceleration of Medpor implant fibrovascularization with local vascular endothelial growth-factor injections: An experimental study. Archives of Clinical and Experimental Surgery (ACES), 4 (4), 196-201. doi:10.5455/aces.20150107042453





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