E-ISSN 2146-8133
 

Original Research (Original Article) 


Impact of surgical procedure artefacts on the hemodynamic parameters of an isoflurane-anesthetized swine cardiopulmonary bypass model

Paul Gavra, André Denault, Cristian Rosu, Louis Perrault, France Varin.

Abstract
Objectives: This study quantifies cardiopulmonary bypass preparation artefacts on mean systemic arterial pressures (mAP), mean pulmonary arterial pressures (mPAP) and their ratio (mAP/mPAP) in order to assess the usefulness of this ratio as a pharmacodynamic marker for pharmacokinetic/pharmacodynamic modeling studies.
Materials and Methods: Fifteen anesthetized swine were monitored every minute before initiation of cardiopulmonary bypass. Percent relative changes from pre-artefact values (Δ%) were used during anesthesia induction and stabilization (Δ% minute-1 reduction rates). In addition, in some animals, amplitude and duration were recorded for the following procedures: sternotomy, pulmonary artery catheter installation, purse-string sutures and cardiac cannulations.
Results: Isoflurane 5% anesthesia induction effect on mAP, lasted on average 5.3±2.0 minutes at 5.9±1.9 Δ% minute-1. Isoflurane 2% anesthesia stabilization effect on mAP lasted on average 36.0±8.0 min at 0.8±0.9 Δ% minute-1. During stabilization, no change in mAP/mPAP was observed (p=0.68). Average amplitudes of artefacts on mAP were 30-50 Δ%; almost twice those observed for mPAP and mAP/mPAP for the same manipulations (p<0.05). Pulmonary artery catheter installation artefacts lasted longer than those of other procedures (p<0.05). Average artefact duration was 4.5±2.5 minutes (n=160).
Conclusions: In isoflurane-anesthetized swine, mAP/mPAP ratio remains constant during anesthesia stabilization, unlike mAP and mPAP individually. Moreover, the ratio shows potential as a pharmacodynamic biomarker for pharmacokinetic/pharmacodynamic studies involving CPB.

Key words: Cardiopulmonary bypass, anesthesia, surgical artefacts, mAP/mPAP, swine


 
ARTICLE TOOLS
Abstract
PDF Fulltext
Print this article Print this Article
How to cite this articleHow to cite this article
Citation Tools
Related Records
 Articles by Paul Gavra
Articles by André Denault
Articles by Cristian Rosu
Articles by Louis Perrault
Articles by France Varin
on Google
on Google Scholar
Article Statistics
 Viewed: 1055
Downloaded: 393
Cited: 0

REFERENCES
1. Haddad F, Guihaire J, Skhiri M, Denault AY, Mercier O, Al-Halabi S. Septal curvature is marker of hemodynamic, anatomical, and electromechanical ventricular interdependence in patients with pulmonary arterial hypertension. Echocardiography 2014;31:699-707. [DOI via Crossref]    [Pubmed]   
2. St-Pierre P, Deschamps A, Cartier R, Basmadjian A, Denault AY. Inhaled milrinone and epoprostenol in a patient with severe pulmonary hypertension, right ventricular failure and reduced baseline brain saturation value from a left atrial myxoma. J Cardiothorac Vasc Anesth 2014;28:723-9. [DOI via Crossref]    [Pubmed]   
3. Laflamme M, Perrault LP, Carrier M, Elmi-Sarabi M, Fortier A, Denault AY. Preliminary experience with combined inhaled milrinone and prostacyclin in cardiac surgical patients with pulmonary hypertension. J Cardiothorac Vasc Anesth 2015;29:38-45. [DOI via Crossref]    [Pubmed]   
4. Denault A, Lamarche Y, Rochon A, Jennifer C, Mark L, Jean-Sébastien L, et al. Innovative approaches in the perioperative care of the cardiac surgical patient in the operating room and intensive care unit. Can J Cardiol 2014;30:S459-S477. [DOI via Crossref]    [Pubmed]   
5. Hubert M, Salazkin I, Desjardins J, Blaise G. Cardiopulmonary bypass surgery in swine: a research model. J Exp Anim Sci 2003;42:135-49. [DOI via Crossref]   
6. Fortier S, DeMaria RG, Lamarche Y, Malo O, Denault A, Desjardins F, et al. Inhaled prostacyclin reduces cardiopulmonary bypass-induced pulmonary endothelial dysfunction via increased cyclic adenosine monophosphate levels. J Thorac Cardio-vasc Surg 2004;128:109-16. [DOI via Crossref]    [Pubmed]   
7. Lamarche Y, Malo O, Thorin E, Denault A, Carrier M, Roy J, et al. Inhaled but not intravenous milrinone prevents pulmonary endothelial dysfunction after cardiopulmonary bypass. J Thorac Cardiovasc Surg 2005;130:83-92. [DOI via Crossref]    [Pubmed]   
8. Hentschel T, Yin N, Riad A, Habbazettl H, Weimann J, Koster A, et al. Inhalation of the phosphodiesterase-3 inhibitor milrinone attenuates pulmonary hypertension in a rat model of congestive heart failure. Anesthesiology 2007;106:124-31. [DOI via Crossref]    [Pubmed]   
9. Robitaille A, Denault AY, Couture P, Belisle S, Fortier A, Guertin MC, et al. Importance of relative pulmonary hypertension in cardiac surgery: the mean systemic-to-pulmonary artery pressure ratio. J Cardiothorac Vasc Anesth 2006;20:331-9. [DOI via Crossref]    [Pubmed]   
10. Aubin MC, Laurendeau S, Mommerot A, Lamarche Y, Denault A, Carrier M, et al. Differential effects of inhaled and intravenous sildenafil in the prevention of the pulmonary endothelial dysfunction due to cardiopulmonary bypass. J Cardiovasc Pharmacol 2008;51:11-7. [DOI via Crossref]    [Pubmed]   
11. Greene Sa, Benson GJ, Tranquilli WJ, Grimm Ka. Effect of isoflurane, atracurium, fentanyl, and noxious stimulation on bispectral index in pigs. Comp Med 2004;54:397-403.
12. Potts AL, Anderson BJ, Holford NH, Vu TC, Warman GR. Dexmedetomidine hemodynamics in children after cardiac surgery. Paediatr Anaesth 2010;20:425-33. [DOI via Crossref]    [Pubmed]   
13. Desborough JP. The stress response to trauma and surgery. Br J Anaesth 2000;85:109-17. [DOI via Crossref]    [Pubmed]   
14. Eisold S, Mehrabi A, Konstantinidis L, Mieth M, Hinz U, Kashfi A, et al. Experimental study of cardiorespiratory and stress factors in esophageal surgery using robot-assisted thoracoscopic or open thoracic approach. Arch Surg 2008;143:156-63. [DOI via Crossref]    [Pubmed]   
15. Schoffmann G, Winter P, Palme R, Pollak A, Trittenwein G, Golej J. Haemodynamic changes and stress responses of piglets to surgery during total intravenous anaesthesia with propofol and fentanyl. Lab Anim 2009;43:243-8. [DOI via Crossref]    [Pubmed]   
16. Moore JP, Hainsworth R, Drinkhill MJ. Phasic negative intrathoracic pressures enhance the vascular responses to stimulation of pulmonary arterial baroreceptors in closed-chest anaesthetized dogs. J Physiol 2004;555:815-24. [DOI via Crossref]    [Pubmed]    [PMC Free Fulltext]   
17. Kittnar O. Cardiac preload: hemodynamic physiology during thoracic surgery. Curr Opin Anaesthesiol 2011;24:21-3. [DOI via Crossref]    [Pubmed]   

How to Cite this Article
Pubmed Style

Gavra P, Denault A, Rosu C, Perrault L, Varin F. Impact of surgical procedure artefacts on the hemodynamic parameters of an isoflurane-anesthetized swine cardiopulmonary bypass model. Arch Clin Exp Surg. 2016; 5(1): 13-20. doi:10.5455/aces.20150813034247


Web Style

Gavra P, Denault A, Rosu C, Perrault L, Varin F. Impact of surgical procedure artefacts on the hemodynamic parameters of an isoflurane-anesthetized swine cardiopulmonary bypass model. http://www.ejmaces.com/?mno=196563 [Access: October 16, 2018]. doi:10.5455/aces.20150813034247


AMA (American Medical Association) Style

Gavra P, Denault A, Rosu C, Perrault L, Varin F. Impact of surgical procedure artefacts on the hemodynamic parameters of an isoflurane-anesthetized swine cardiopulmonary bypass model. Arch Clin Exp Surg. 2016; 5(1): 13-20. doi:10.5455/aces.20150813034247



Vancouver/ICMJE Style

Gavra P, Denault A, Rosu C, Perrault L, Varin F. Impact of surgical procedure artefacts on the hemodynamic parameters of an isoflurane-anesthetized swine cardiopulmonary bypass model. Arch Clin Exp Surg. (2016), [cited October 16, 2018]; 5(1): 13-20. doi:10.5455/aces.20150813034247



Harvard Style

Gavra, P., Denault, A., Rosu, C., Perrault, L. & Varin, F. (2016) Impact of surgical procedure artefacts on the hemodynamic parameters of an isoflurane-anesthetized swine cardiopulmonary bypass model. Arch Clin Exp Surg, 5 (1), 13-20. doi:10.5455/aces.20150813034247



Turabian Style

Gavra, Paul, André Denault, Cristian Rosu, Louis Perrault, and France Varin. 2016. Impact of surgical procedure artefacts on the hemodynamic parameters of an isoflurane-anesthetized swine cardiopulmonary bypass model. Archives of Clinical and Experimental Surgery (ACES), 5 (1), 13-20. doi:10.5455/aces.20150813034247



Chicago Style

Gavra, Paul, André Denault, Cristian Rosu, Louis Perrault, and France Varin. "Impact of surgical procedure artefacts on the hemodynamic parameters of an isoflurane-anesthetized swine cardiopulmonary bypass model." Archives of Clinical and Experimental Surgery (ACES) 5 (2016), 13-20. doi:10.5455/aces.20150813034247



MLA (The Modern Language Association) Style

Gavra, Paul, André Denault, Cristian Rosu, Louis Perrault, and France Varin. "Impact of surgical procedure artefacts on the hemodynamic parameters of an isoflurane-anesthetized swine cardiopulmonary bypass model." Archives of Clinical and Experimental Surgery (ACES) 5.1 (2016), 13-20. Print. doi:10.5455/aces.20150813034247



APA (American Psychological Association) Style

Gavra, P., Denault, A., Rosu, C., Perrault, L. & Varin, F. (2016) Impact of surgical procedure artefacts on the hemodynamic parameters of an isoflurane-anesthetized swine cardiopulmonary bypass model. Archives of Clinical and Experimental Surgery (ACES), 5 (1), 13-20. doi:10.5455/aces.20150813034247





Most Viewed Articles
  • Hirudotherapy /Leech therapy: Applications and Indications in Surgery
    Swaid Abdullah, Latief M. Dar, Adil Rashid, Anita Tewari
    Arch Clin Exp Surg. 2012; 1(3): 172-180
    » Abstract & References » doi: 10.5455/aces.20120402072447

  • Role of Probiotics in Dental Caries and Periodontal Disease
    Amit Bhardwaj, Shalu V Bhardwaj
    Arch Clin Exp Surg. 2012; 1(1): 45-49
    » Abstract & References » doi: 10.5455/aces.20120212100645

  • Use of Polyethylene Fiber (Ribbond) in Pediatric Dentistry
    Eda Arat Maden, Ceyhan Altun
    Arch Clin Exp Surg. 2012; 1(2): 110-115
    » Abstract & References » doi: 10.5455/aces.20120416115640

  • Attenuated familial adenomatous polyposis presenting as an abdominal wall mass
    Marc Paul Jose Lopez, John Paul Senon Gonzalez, Manuel Francisco Tanada Roxas
    Arch Clin Exp Surg. 2017; 6(1): 53-55
    » Abstract » doi: 10.5455/aces.20150809085449

  • Role of Ultrasonography (“Honeycomb Sign”) in Early Detection of Dengue Hemorrhagic Fever
    Sudhir Sachar, Sunder Goyal, Saurabh Sachar
    Arch Clin Exp Surg. 2013; 2(1): 38-42
    » Abstract & References » doi: 10.5455/aces.20120828025157

  • Barium Enema in the Diagnosis of Hirschsprung’s Disease: A Comparison with Rectal Biopsy
    Mohammad Abbas, Arshad Rashid, Asim Rafiq Laharwal, Ajaz Ahmad Wani, Shabir Ahmad Dar, Manzoor Ahamad Chalkoo, Showkat Majeed Kakroo
    Arch Clin Exp Surg. 2013; 2(4): 224-228
    » Abstract & References » doi: 10.5455/aces.20120703031135

  • Long-Term Productive Cough Caused by Tracheal Bronchus
    Chih-Hao Chen, Shih-Yi Lee, Ho Chang, Tzu-Ti Hung
    Arch Clin Exp Surg. 2012; 1(2): 120-121
    » Abstract & References » doi: 10.5455/aces.20120311102403

  • A Review of the Prevention and Treatment of Hypertrophic Scars: Part I Clinical Aspects
    Huseyin Karagoz, Celalettin Sever, Yalcin Bayram, Cihan Sahin, Yalcin Kulahci, Ersin Ulkur
    Arch Clin Exp Surg. 2012; 1(4): 237-248
    » Abstract & References » doi: 10.5455/aces.20120218124923

  • Day–Care Surgery for Pilonidal Sinus Using Sinotomy Technique and Fibrin Glue Injection
    Selim Sozen, Vedat Ozturk, Koray Das, Hasan Erdem, Suleyman Cetinkunar, Ilhan Bali
    Arch Clin Exp Surg. 2012; 1(3): 138-141
    » Abstract & References » doi: 10.5455/aces.20120625121721

  • Patient Selection in Plastic Surgery: Recognizing Body Dysmorphic Disorder
    Cihan Sahin, Onat Yilmaz, Yalcin Bayram, Huseyin Karagoz, Celalettin Sever, Yalcin Kulahci, Alpay Ates
    Arch Clin Exp Surg. 2013; 2(2): 109-115
    » Abstract & References » doi: 10.5455/aces.20120722123102

  • Most Downloaded
  • Attenuated familial adenomatous polyposis presenting as an abdominal wall mass
    Marc Paul Jose Lopez, John Paul Senon Gonzalez, Manuel Francisco Tanada Roxas
    Arch Clin Exp Surg. 2017; 6(1): 53-55
    » Abstract » doi: 10.5455/aces.20150809085449

  • Role of Probiotics in Dental Caries and Periodontal Disease
    Amit Bhardwaj, Shalu V Bhardwaj
    Arch Clin Exp Surg. 2012; 1(1): 45-49
    » Abstract & References » doi: 10.5455/aces.20120212100645

  • Hirudotherapy /Leech therapy: Applications and Indications in Surgery
    Swaid Abdullah, Latief M. Dar, Adil Rashid, Anita Tewari
    Arch Clin Exp Surg. 2012; 1(3): 172-180
    » Abstract & References » doi: 10.5455/aces.20120402072447

  • Patient Selection in Plastic Surgery: Recognizing Body Dysmorphic Disorder
    Cihan Sahin, Onat Yilmaz, Yalcin Bayram, Huseyin Karagoz, Celalettin Sever, Yalcin Kulahci, Alpay Ates
    Arch Clin Exp Surg. 2013; 2(2): 109-115
    » Abstract & References » doi: 10.5455/aces.20120722123102

  • Use of Polyethylene Fiber (Ribbond) in Pediatric Dentistry
    Eda Arat Maden, Ceyhan Altun
    Arch Clin Exp Surg. 2012; 1(2): 110-115
    » Abstract & References » doi: 10.5455/aces.20120416115640

  • A Study of Methods Used to Reduce Surgical Site Infections
    Stuart R. Walker, Tara Anderson
    Arch Clin Exp Surg. 2012; 1(1): 27-33
    » Abstract & References » doi: 10.5455/aces.20120213053645

  • Principles of risk management in surgery departments
    Fatemeh Rezaei, Mohammad H Yarmohammadian, Masoud Ferdosi, Abbas Haghshenas
    Arch Clin Exp Surg. 2015; 4(3): 126-134
    » Abstract & References » doi: 10.5455/aces.20140925015830

  • Slow-Release Drug Deliver System with Polylactic Acid Hydrogels in Prevention of Tracheal Wall Fibroplasia
    Jinrang Li, Lili Peng, Jianjun Sun, Hongguang Guo, Kun Guo, Zuogang Li, Yao Tang, Xu Sun, Shuangqing Zhang
    Arch Clin Exp Surg. 2012; 1(1): 1-7
    » Abstract & References » doi: 10.5455/aces.20120220105531

  • Post-Traumatic Pancreatic Pseudocyst: Report of Two Cases with Review of Literature
    Sunder Goyal, Sudhir Sachar, Ram Kumar Verma, Snigdha Goyal
    Arch Clin Exp Surg. 2013; 2(4): 251-258
    » Abstract & References » doi: 10.5455/aces.20120524103614

  • Role of Ultrasonography (“Honeycomb Sign”) in Early Detection of Dengue Hemorrhagic Fever
    Sudhir Sachar, Sunder Goyal, Saurabh Sachar
    Arch Clin Exp Surg. 2013; 2(1): 38-42
    » Abstract & References » doi: 10.5455/aces.20120828025157

  • Most Cited Articles
  • Hirudotherapy /Leech therapy: Applications and Indications in Surgery
    Swaid Abdullah, Latief M. Dar, Adil Rashid, Anita Tewari
    Arch Clin Exp Surg. 2012; 1(3): 172-180
    » Abstract & References » doi: 10.5455/aces.20120402072447
    Cited : 8 times [Click to see citing articles]

  • Experimental Craniofacial Composite Tissue Allotransplantation (CCTA) Models in Rats
    Yalcin Kulahci, Yalcin Bayram, Huseyin Karagoz, Celalettin Sever, Cihan Sahin
    Arch Clin Exp Surg. 2012; 1(3): 181-187
    » Abstract & References » doi: 10.5455/aces.20120514010906
    Cited : 7 times [Click to see citing articles]

  • Thoracodorsal Artery Perforator Flap: Basic Surgical Determinants
    Celalettin Sever, Yalcin Bayram, Cihan Sahin
    Arch Clin Exp Surg. 2012; 1(4): 270-271
    » Abstract & References » doi: 10.5455/aces.20120506072849
    Cited : 6 times [Click to see citing articles]

  • Pre-expanded Supraclavicular Flap for Post-burn Neck Contractures
    Celalettin Sever, Cihan Sahin
    Arch Clin Exp Surg. 2012; 1(1): 61-62
    » Abstract & References » doi: 10.5455/aces.20120205090034
    Cited : 4 times [Click to see citing articles]

  • Day–Care Surgery for Pilonidal Sinus Using Sinotomy Technique and Fibrin Glue Injection
    Selim Sozen, Vedat Ozturk, Koray Das, Hasan Erdem, Suleyman Cetinkunar, Ilhan Bali
    Arch Clin Exp Surg. 2012; 1(3): 138-141
    » Abstract & References » doi: 10.5455/aces.20120625121721
    Cited : 4 times [Click to see citing articles]

  • The effect of Kristeller maneuver on maternal and neonatal outcome
    Gokhan Acmaz, Evrim Albayrak, Gokalp Oner, Murvet Baser, Gulsum Aykut, Gulender Tas Tekin, Gokmen Zararsiz, Iptisam Ipek Muderris
    Arch Clin Exp Surg. 2015; 4(1): 29-35
    » Abstract & References » doi: 10.5455/aces.20140328024258
    Cited : 4 times [Click to see citing articles]

  • What is the Most Appropriate Animal Model for Experimental Diabetic Neuropathy Studies ?
    Huseyin Karagoz, Mustafa Tansel Kendirli
    Arch Clin Exp Surg. 2012; 1(3): 199-200
    » Abstract & References » doi: 10.5455/aces.20120514012617
    Cited : 3 times [Click to see citing articles]

  • Anesthetic Burns – A Burn Injury Due to A Combination of Local Anaesthetic and Heat Pack
    Stuart Robert Walker
    Arch Clin Exp Surg. 2012; 1(2): 127-128
    » Abstract & References » doi: 10.5455/aces.20120206110836
    Cited : 3 times [Click to see citing articles]

  • A Review of the Prevention and Treatment of Hypertrophic Scars: Part I Clinical Aspects
    Huseyin Karagoz, Celalettin Sever, Yalcin Bayram, Cihan Sahin, Yalcin Kulahci, Ersin Ulkur
    Arch Clin Exp Surg. 2012; 1(4): 237-248
    » Abstract & References » doi: 10.5455/aces.20120218124923
    Cited : 3 times [Click to see citing articles]

  • A Review of the Prevention and Treatment of Hypertrophic Scars: Part II. Experimental Studies
    Huseyin Karagoz, Yalcin Bayram, Celalettin Sever, Cihan Sahin, Yalcin Kulahci, Ersin Ulkur
    Arch Clin Exp Surg. 2013; 2(1): 49-58
    » Abstract & References » doi: 10.5455/aces.20120218125115
    Cited : 3 times [Click to see citing articles]