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Haematological splenomegaly does not directly relate to portal hypertension: From a clinical study to surgical choice

Antonio Manenti, Fabio Forghieri, Maurizio Zizzo, Dario Colasanto, Mario Luppi.

Abstract
Background: Splenomegaly induces an increased inflow into the portal venous system; however, in the absence of pathology of the liver and of a portal vein system, secondary portal hypertension is unusual. We analyzed this problem through a clinical observational method.
Methods: We selected 20 patients with splenomegaly secondary to B-cell chronic lymphocytic leukaemia; their imaging tests and clinical pathways were re-examined.
Results: In the absence of diseases of the liver or of the portal venous system, an increased portal blood flow, secondary to the splenomegaly, could not be considered the sole cause of portal hypertension.
Conclusions: The normal liver has a high venous capacity, and in the absence of other factors, the sole increase in portal venous flow cannot directly justify portal hypertension. This conclusion is still well founded, even if multiple humoral mediators, some of which are also released from the spleen in a number of pathological conditions, can differentially modulate the haemodynamics of hepatic sinusoids.

Key words: Splenomegaly, portal hypertension, chronic lymphocytic leukaemia


 
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How to Cite this Article
Pubmed Style

Manenti A, Forghieri F, Zizzo M, Colasanto D, Luppi M. Haematological splenomegaly does not directly relate to portal hypertension: From a clinical study to surgical choice. Arch Clin Exp Surg. 2017; 6(2): 86-90. doi:10.5455/aces.20160402123939


Web Style

Manenti A, Forghieri F, Zizzo M, Colasanto D, Luppi M. Haematological splenomegaly does not directly relate to portal hypertension: From a clinical study to surgical choice. http://www.ejmaces.com/?mno=219772 [Access: May 27, 2018]. doi:10.5455/aces.20160402123939


AMA (American Medical Association) Style

Manenti A, Forghieri F, Zizzo M, Colasanto D, Luppi M. Haematological splenomegaly does not directly relate to portal hypertension: From a clinical study to surgical choice. Arch Clin Exp Surg. 2017; 6(2): 86-90. doi:10.5455/aces.20160402123939



Vancouver/ICMJE Style

Manenti A, Forghieri F, Zizzo M, Colasanto D, Luppi M. Haematological splenomegaly does not directly relate to portal hypertension: From a clinical study to surgical choice. Arch Clin Exp Surg. (2017), [cited May 27, 2018]; 6(2): 86-90. doi:10.5455/aces.20160402123939



Harvard Style

Manenti, A., Forghieri, F., Zizzo, M., Colasanto, D. & Luppi, M. (2017) Haematological splenomegaly does not directly relate to portal hypertension: From a clinical study to surgical choice. Arch Clin Exp Surg, 6 (2), 86-90. doi:10.5455/aces.20160402123939



Turabian Style

Manenti, Antonio, Fabio Forghieri, Maurizio Zizzo, Dario Colasanto, and Mario Luppi. 2017. Haematological splenomegaly does not directly relate to portal hypertension: From a clinical study to surgical choice. Archives of Clinical and Experimental Surgery (ACES), 6 (2), 86-90. doi:10.5455/aces.20160402123939



Chicago Style

Manenti, Antonio, Fabio Forghieri, Maurizio Zizzo, Dario Colasanto, and Mario Luppi. "Haematological splenomegaly does not directly relate to portal hypertension: From a clinical study to surgical choice." Archives of Clinical and Experimental Surgery (ACES) 6 (2017), 86-90. doi:10.5455/aces.20160402123939



MLA (The Modern Language Association) Style

Manenti, Antonio, Fabio Forghieri, Maurizio Zizzo, Dario Colasanto, and Mario Luppi. "Haematological splenomegaly does not directly relate to portal hypertension: From a clinical study to surgical choice." Archives of Clinical and Experimental Surgery (ACES) 6.2 (2017), 86-90. Print. doi:10.5455/aces.20160402123939



APA (American Psychological Association) Style

Manenti, A., Forghieri, F., Zizzo, M., Colasanto, D. & Luppi, M. (2017) Haematological splenomegaly does not directly relate to portal hypertension: From a clinical study to surgical choice. Archives of Clinical and Experimental Surgery (ACES), 6 (2), 86-90. doi:10.5455/aces.20160402123939





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