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A Rat Carotid Model with Direct Stent Implantation for the Study of Thrombosis and Restenosis

Abstract

Gary K. Yang, Kai Yu, Jayachandran Kizhakkedathu, York N. Hsiang*

Atherosclerosis is the leading cause of coronary and peripheral arterial disease and research surrounding its treatment using endovascular stents remains an important area of medical research. This paper describes an in vivo rat model for studying the physiological response to intravascular stent implantation. The carotid artery is isolated and retrograde stent implantation is accessed via the external carotid artery and advanced into the common carotid artery. Following this, the external carotid artery is ligated and the rats recovered. Two weeks later, the rats are euthanized and the common carotid artery containing the stent collected and processed to assess the stent impact on the native artery. Future experiments can utilize this model to better understand the process of thrombosis and intimal hyperplasia. In addition, newer stent designs and coatings can also be investigated in a similar manner.

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